Six coordination compounds: mode of cytotoxic action and biological evaluation
نویسندگان
چکیده
منابع مشابه
Evaluation of the metal-dependent cytotoxic behaviour of coordination compounds.
The [Cu(L)Cl2]2 and [Pt(L)Cl2] complexes were prepared from the simple Schiff-base ligand (E)-phenyl-N-((pyridin-2-yl)methylene)methanamine (L) and respectively, CuCl2 and cis-[PtCl2(DMSO)2]. DNA-interaction studies revealed that the copper complex most likely acts as a DNA cleaver whereas the platinum complex binds to the double helix. Remarkably, cell-viability experiments with HeLa, MCF7 and...
متن کاملDiaminic carbonates, a new class of anti-inflammatory compounds: their biological characterization and mode of action.
Taking advantage of a standard assay on mouse LM cells (murine fibroblast-like cells), we found that several diaminic carbonates, a new class of organic compounds synthesized in our laboratories, were able to inhibit human tumor necrosis factor alpha (huTNFalpha)-induced cytotoxicity in a dose-dependent manner. Structure-function relationship studies indicated precise structural requirements fo...
متن کامل“synthesis and Characterization of Novel Coordination Compounds Having Biological Significance”
OF THE THESIS Submitted for the award of the degree of Doctor of Philosophy IN CHEMISTRY
متن کاملBiological and Clinical Aspects of Lanthanide Coordination Compounds
The coordinating chemistry of lanthanides, relevant to the biological, biochemical and medical aspects, makes a significant contribution to understanding the basis of application of lanthanides, particularly in biological and medical systems. The importance of the applications of lanthanides, as an excellent diagnostic and prognostic probe in clinical diagnostics, and an anticancer material, is...
متن کاملStructure, activity and mode of action of antitumor platinum compounds
Chantitative relationship beween activity and structure of antitumor platinum complexes was studied by C W / 2 method. On the basis of the obtained regression results, some new platinum complexes with methyl substituted aliphatic and cycloaliphatic mines were synthesized and screened, and a new complex [Pt(~PDA)(Cl-Ac),l possessing high activity as cisplatin but with much laver toxicity was fou...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the Turkish Chemical Society, Section A: Chemistry
سال: 2016
ISSN: 2149-0120
DOI: 10.18596/jotcsa.37363